NFL

New Study Estimates CTE Prevalence in Former NFL Players at 25 Percent

  • Authored By: Sports Now
  • Updated Aug 25, 2026, 20:07 IST

A recent study published in the British Medical Journal indicates that at least one in four NFL players who passed away between 2016 and 2021 suffered from the degenerative brain condition known as CTE.

New Study Estimates CTE Prevalence in Former NFL Players at 25 Percent

A significant new study published in the British Medical Journal has shed light on the prevalence of chronic traumatic encephalopathy (CTE) among professional football players. The research, released on Tuesday, indicates that at least 25 percent of NFL players who died between 2016 and 2021 were affected by the degenerative brain disease.

The investigation examined data from 878 individuals who had appeared in at least one NFL game and passed away during that six-year window. Because CTE can currently only be diagnosed post-mortem, researchers utilized brain donations provided between 2008 and 2021, incorporating demographic data and death certificate information to reach their findings.

Understanding the Scope and Risks of CTE

Dr. Daniel Daneshvar, the lead author of the study, noted that the 25 percent figure represents the low end of the estimate. While the research suggested a maximum possible prevalence of approximately 97 percent, Daneshvar stated that the true rate likely sits somewhere in the middle. The study also highlighted a strong correlation between the disease and cognitive decline, finding that over 90 percent of samples exhibiting Stage IV CTE—the most advanced stage—were also diagnosed with dementia.

Daneshvar emphasized that the cumulative force of head impacts remains the primary predictor for developing the condition. He suggested that risks could potentially be mitigated through measures such as reducing contact during practice sessions and delaying the introduction of tackle football for children.

Industry Responses and Player Perspectives

In response to the findings, the NFLPA issued a statement describing the study as a sobering reminder of the risks associated with the sport. The association reaffirmed its commitment to prioritizing player safety and supporting athletes throughout their careers and beyond, calling the results a necessary call to action for the entire football ecosystem to advance research and improve access to care.

The NFL also addressed the report, stating that the league remains dedicated to making the game safer by implementing strategies designed to reduce concussions and head impacts. The league noted that it continues to provide an expanding set of resources to support the physical and mental well-being of the NFL community.

For active players, the physical toll of the sport remains a known reality. Houston Texans linebacker Azeez Al-Shaair, entering his eighth season, acknowledged the aggressive nature of the game. He noted that players are aware of the risks involved when they sign up to compete at the professional level, emphasizing the importance of taking care of one's body off the field to maintain health. Researchers intend to build upon these findings with a follow-up study in the coming months aimed at estimating the overall rate of CTE among all NFL players at the time of their death.