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Pierce, who initially exited the game late in the first quarter unable to put weight on his left leg, had been managing the issue since undergoing surgery in March. Although his rehabilitation kept him out of the preseason, he managed to return for the season opener before suffering the setback early in Week 2. Following consultations with multiple physicians, the team has opted for a rehabilitation-focused recovery plan, with surgery currently not under consideration.
Impact on the Colts Offense and Roster Adjustments
The absence of Pierce presents a notable challenge for the Indianapolis offense. Recognized as one of the league's most effective deep threats, he has led the NFL in yards per catch over the previous two seasons. His limited availability—playing just 41% of snaps through the first two weeks—has coincided with a dip in efficiency for quarterback
In response to the vacancy, the Colts have moved to bolster their receiving corps. Earlier this week, the organization signed veteran wideout Darius Slayton, formerly of the New York Giants. Additionally, the team promoted Anthony Gould from the practice squad on Saturday. To provide further depth for their upcoming matchup against the Houston Texans, the Colts also elevated Nick Westbrook-Ikhine from the practice squad.
Under the current injured reserve rules, Pierce is ineligible to return to the active roster for a minimum of four weeks. His earliest possible return date is now set for the Colts' October 25 contest against the Minnesota Vikings.
